Molecular profile & clinical outcome in 121 cases - experience from a tertiary referral centre in South India

Ewing sarcoma is the second most common involving bones in children and adolescents. Published data on clinical features, morphology, translocation follow-up of patients with from India, sparse. Objectives this study were to analyse clinico-pathologic features compare status, BCoR immunohistochemistry, treatment survival. 406 cases diagnosed Department Pathology, Christian Medical College, Vellore during period 2008-2015. 135 underwent molecular testing for translocations by RT-PCR included study. Mean age at diagnosis was 22 years. Most location tumour appendicular skeleton (31.4%) 19% had solid organ involvement. Distant metastasis present 21.5% patients. Translocation seen 63 (46.7%) cases, EWS-FLI1 type I (87%), II(11%) one patient EWS-ERG translocation. Seven out 30 classified as “Sarcoma BCOR genetic alteration”. Patients who 6 cycles chemotherapy a better mean 13.72 months 3 year event free survival 93.8%. Percentage viable <10% only significant histologic parameter predicting Age ≤15yrs, female sex, size ≤12cm, extra-osseous site, positivity predicted an improved This has analysed mutations/translocations subset Indian correlated pathological factors affecting